Why Patients Choose Liondale Medical for TPE in NYC

Liondale Medical is one of three NYC practices currently offering therapeutic plasma exchange for longevity. What separates it is not a louder claim. It is the care model: physician-led oversight by Lionel Bissoon, D.O., a Circulate Health partnership that informs how the practice approaches TPE, pre- and post-treatment lab tracking with every session, and a concierge structure that places TPE inside a broader medical plan instead of treating it as a one-off purchase. Dr. Bissoon personally reviews every case. If you want the clinical overview first, start with therapeutic plasma exchange at Liondale Medical.

Patients searching for the best TPE clinic in NYC are usually asking a more useful question: who is running the protocol, what gets measured and what happens if the numbers do not move? That is where Liondale’s model matters. This is a private Upper West Side practice built for people who want continuity, screening and a doctor who knows the rest of their longevity plan.

Dr. Lionel Bissoon, D.O.: Who Is Running Your Protocol

The first thing I would want to know before booking TPE anywhere is which physician is responsible for my care. At Liondale, that is Dr. Lionel Bissoon, D.O., a board-certified osteopathic physician specializing in anti-aging and concierge medicine on the Upper West Side. He is not a remote sign-off, and he is not a name on the website while someone else makes the day-to-day decisions. You can read more on his provider page.

In a high-ticket category, some practices separate the consult from the protocol review and the treatment day. Liondale’s structure is tighter. Dr. Bissoon reviews your history, medications, baseline labs, goals and how TPE fits with the rest of your care before the first session is scheduled. That continuity matters because TPE is an apheresis procedure with real contraindications, real cost and real decision points around timing, frequency and IVIG. A nurse may run the treatment session, as is appropriate in apheresis care, but protocol direction stays physician-led from start to finish. For a deeper look at this distinction, see physician-led versus nurse-led longevity clinics.

It matters on the back end too. Dr. Bissoon reviews what changed after treatment. If the intervention is doing what it should, the plan continues with confidence. If not, we reassess rather than repeat the calendar because that is what a package says. Liondale’s TPE program is built around physician judgment, not throughput.

The Circulate Health Partnership: What It Actually Means

Liondale is a Circulate Health partner. That does not mean a logo on a brochure. It means Liondale uses a Circulate-informed TPE model tied to the evidence base that brought TPE into the national longevity conversation. Circulate collaborated with the Buck Institute for Research on Aging on the 2025 Aging Cell trial, a randomized, placebo-controlled study of 42 healthy adults over 50. TPE plus IVIG produced an average biological age reduction of 2.61 years, and TPE alone produced 1.32 years. It is the strongest direct human evidence in this category, and it is still early. For the deeper breakdown, read our analysis of the clinical trial evidence.

In practice, the partnership means our clinical framework, lab-tracking approach and IVIG evaluation process are informed by Circulate’s work. It is not a claim that Liondale runs the exact trial protocol or that outcomes will match the study. It is a claim that our approach connects to a serious evidence base instead of being improvised from a headline. Circulate’s work has been covered by the New York Times, Fortune, CNET, the Washington Post and Axios, and Circulate patient surveys report 90% satisfaction, which is a patient-experience metric, not a clinical endpoint.

How Liondale’s Model Differs From Other NYC TPE Clinics

There are three confirmed NYC providers offering TPE for longevity: Liondale Medical, Extension Health and Next Health. Each has a real angle. For a factual side-by-side, see our NYC TPE clinic comparison.

The relevant question here is not which clinic is cheapest or has the most locations. It is which care model fits a patient who wants physician-led, lab-tracked, concierge-level TPE with protocol flexibility and continuity. Liondale’s lane is smaller and more personal: one physician oversees your protocol across consult, screening, lab review, session planning and follow-up, and TPE sits inside a concierge longevity practice, not beside it. If you are also working on hormones, NAD+, ozone or regenerative care, the same practice can coordinate the sequence.

Liondale also does not force everyone into fixed-session thinking. A patient who needs a tighter initial cadence and a patient who should space sessions further apart should not be sold the same answer because it packages well. For a cost view of what each model includes, see TPE cost in NYC.

Pre- and Post-Treatment Lab Tracking

This is one of the biggest reasons patients choose Liondale. Every session is tracked with pre- and post-treatment labs: inflammatory markers such as CRP, IL-6 and fibrinogen, plus a metabolic panel and lipid panel, and where clinically sensible, epigenetic clock biomarkers. The point is to know whether the intervention is moving anything objective. Without data, TPE can drift into guesswork. A patient may feel better for a week, which is good to hear, but did inflammation change? Did a metabolic marker move?

Kevin MacDonald, a Circulate patient, said it well: “Watching all my bloodwork numbers move into or towards the green gives me a lot of confidence in what I’m doing with TPE.” That is the standard thoughtful patients want. Evidence, not applause after a session. And when markers do not move, the answer is not to pretend they did. We can change frequency, reconsider IVIG, adjust the broader plan or decide TPE is not the best next step. Our full method is in how Liondale tracks TPE results.

The Concierge Model: What That Means in Practice

Concierge care gets described badly. Here it means privacy, continuity and enough clinical bandwidth to think across your whole case instead of only the procedure in front of you. Liondale is a boutique Upper West Side practice. Patients are not moving through a high-volume floor with a rotating cast of staff. The setting is quieter and the relationship closer. For many TPE patients, especially those whose longevity plan is already complex, that is the reason they book. For more on how concierge practices differ from traditional ones, see concierge medicine explained.

It also means TPE does not exist in isolation. Many patients are already working through a bigger strategy that may include concierge medicine, hormone care, NAD+ support, ozone or regenerative treatment planning. Those decisions affect timing, recovery, hydration strategy, lab interpretation and what success looks like. When one physician has the full picture, sequencing is cleaner. You are not just buying the session. You are buying continuity around it. Read more on concierge longevity medicine in NYC.

What Your First Visit Looks Like

The first visit is a consultation, not a treatment day. Dr. Bissoon reviews your medical history, medications, recent labs and goals. If TPE looks appropriate, baseline labs are drawn before any session is scheduled, and your protocol is designed from that picture. If TPE is not appropriate, we say so and discuss alternatives. Pricing is discussed at consultation because it depends on your protocol. No referral is required. Bring recent bloodwork, a medication and supplement list and your questions. For candidacy details, read is TPE safe and who should consider it.

Location, Hours and Contact

Liondale Medical is at 10 West 74th Street, Suite 1E, New York, NY 10023, on the Upper West Side. Call 212-579-9136 or contact the practice to schedule. You can also read patient testimonials and see our Upper West Side location page.

What This Practice Is Not

I do not think TPE should be sold as a status purchase, and I do not think every patient who can afford it should do it. If someone wants the most aggressive protocol because it sounds impressive, that is not enough for me. I want to know the history, medications, goals and what the baseline says first.

Liondale is not a volume clinic and not a chain. It is not built around selling the biggest package to everyone who asks. If I think TPE is the wrong fit, I would rather say so than force the case. Good medicine loses some sales, and that is fine. The practice is selective, physician-led, lab-tracked and honest about candidacy.

Questions Patients Ask Before Choosing a Clinic

Patients who reach this page have usually already read about TPE and are now comparing clinics. The questions we hear most often are practical. Will I see the physician, or only a coordinator? What exactly is measured before and after each session? What happens if my numbers do not change? Is IVIG part of the plan, and who decides? What does the first visit involve, and do I have to commit to a package that day? These are the right questions, and a clinic that answers them plainly is usually confident in its process. At Liondale, the answers are consistent: the physician who designs your plan is the physician who reviews it, every session is measured, and every recommendation is tied to your history and labs. We would rather have a patient decide slowly and with full information than commit quickly and feel uncertain later. If you would like to see the evidence behind our approach before booking, our analysis of the 2025 trial and our cost guide are good places to start. Your first conversation should leave you better informed, whether or not you decide to proceed, and that is the standard we hold ourselves to.

Frequently Asked Questions

Who reviews candidacy and follow-up at Liondale?

Dr. Bissoon personally. Not a coordinator and not a remote physician. He reviews your history, labs, medications and treatment response at every stage, from the initial consult through ongoing maintenance.

Is Liondale actually affiliated with Circulate Health?

Yes. Liondale is a Circulate Health partner. In practical terms, our TPE program is informed by the same protocol family, lab-tracking approach and IVIG evaluation logic connected to the 2025 Buck Institute and Aging Cell trial. It is an operational relationship, not just a badge.

What makes physician-led TPE different from a nurse-led model?

Apheresis nurses are essential to safe delivery, but protocol decisions should be physician decisions. Physician-led means candidacy, medication review, lab interpretation, session timing and any change in plan are directed by a doctor who has reviewed the full case.

Where is Liondale Medical located?

Liondale is at 10 West 74th Street, Suite 1E, New York, NY 10023, on the Upper West Side. The phone number is 212-579-9136.

Do you take insurance for TPE?

For longevity use, TPE is generally self-pay. Insurance coverage is tied to established medical indications, not elective anti-aging protocols. Our TPE cost page lays out the market.

How do I know if I’m the right fit before booking?

Start with a consultation and baseline review. Stronger candidates are usually adults serious about prevention who want a measured intervention, or patients with persistent fatigue, brain fog, slower recovery or inflammatory burden not explained by basic workups. There are real contraindications, and we take a conservative view of candidacy.

Can I do TPE here alongside other longevity treatments?

Often, yes. TPE can sit inside a broader plan alongside concierge care, hormone work, NAD+, ozone or regenerative planning, sequenced under one physician. Sometimes that means combining therapies and sometimes spacing them out.

Do I need a referral to see Dr. Bissoon for TPE?

No. Contact us directly to schedule a consultation.

How much does TPE cost at Liondale?

Pricing is discussed at consultation because it depends on your protocol, including IVIG, the number of sessions and whether labs are on file. Published NYC pricing runs about $8,000 to $10,000 per session across clinics.

What happens if my markers don’t improve?

We do not pretend they did. Dr. Bissoon reviews the pattern and may change frequency, reconsider IVIG, adjust the broader plan or recommend stopping.

If that approach sounds right to you, the next step is a direct consultation, not a blind package purchase. Contact Liondale Medical to discuss fit, timing and whether TPE belongs in your plan at all, or read about our TPE program first.

Published May 27th, 2026