Therapeutic Plasma Exchange in NYC: Where It's Offered, What It Costs, and How to Choose

Three clinics in New York City currently offer therapeutic plasma exchange (TPE, also called plasmapheresis) for longevity: Liondale Medical on the Upper West Side, Extension Health in the West Village and Midtown East, and Next Health in Flatiron. Published pricing runs roughly $8,000 to $10,000 per session, and what that price includes varies a great deal. This guide compares the three on the things that matter clinically, then explains what a session involves, how long it takes, and what to ask before you book. If you want the full clinical overview of our own program first, start with therapeutic plasma exchange at Liondale Medical.

TPE, Plasmapheresis, and “Blood Oil Change”: Same Procedure, Different Names

These terms all describe the same core procedure. Blood is drawn through an apheresis machine, the plasma (the liquid portion of blood) is separated and removed, and your blood cells are returned to you with a replacement fluid, usually albumin. “Plasmapheresis” is the older term and is common in hospital and autoimmune settings. “Therapeutic plasma exchange” is the language most longevity clinics use. “Blood oil change” is a lay phrase popularized by podcasters and social media.

One caution on that last term. Some clinics use “blood cleaning” or “blood oil change” for other extracorporeal treatments, such as EBO2, that pass blood through a filter or treat it with oxygen and ozone but do not replace plasma. If a clinic is offering something under one of these names, ask whether plasma is actually being removed and replaced. Our page on EBO2 therapy in NYC explains how that treatment differs.

NYC TPE Clinics at a Glance

	Liondale Medical	Extension Health	Next Health
Location	Upper West Side	West Village and Midtown East	Flatiron
Model	Boutique concierge practice	Physician-led independent practice	National membership chain (15+ locations)
Physician	Lionel Bissoon, D.O.	Dr. Albert Kuo	Chain-based clinical structure
Published pricing	Discussed at consultation	$10,000 per session, self-pay	$24,000 for three sessions; $45,000 for six
Lab tracking	Pre- and post-treatment panels with each session	Ask the clinic what is measured	Baseline Test and Total Tox Burden Test
Notable feature	Circulate Health partner; TPE integrated with hormones, NAD+ and other longevity care	Published BPA-reduction data; two locations	Bundled with aesthetics and IV services

Pricing and program details are taken from each clinic’s published information and can change, so confirm current terms directly.

Liondale Medical: Upper West Side

Liondale is a private practice founded and led by Dr. Lionel Bissoon, D.O., a board-certified osteopathic physician. We are a Circulate Health partner. Circulate is the organization that collaborated with the Buck Institute for Research on Aging on the 2025 clinical trial that produced the strongest human data on TPE and biological age to date. Our approach to patient selection, lab monitoring and IVIG decisions is informed by that work. That does not mean your results will match the trial. It means our decisions are grounded in the same evidence base.

What distinguishes how we practice:

• Dr. Bissoon reviews every protocol personally. A nurse operates the apheresis machine, as is appropriate, but the physician who designed your plan directs it.
• Every session is bracketed by labs. Pre- and post-treatment panels cover inflammatory markers, a metabolic panel and, where appropriate, biological age biomarkers. We explain exactly what we measure and why in how Liondale tracks TPE results.
• TPE sits inside a broader plan. Patients who are also managing hormones, NAD+ or other longevity care get one physician coordinating the sequence.

We do not post a per-session price because cost depends on your protocol: whether IVIG is included, how many sessions you need, and whether recent labs are already on file. The TPE cost guide explains the variables.

Extension Health: West Village and Midtown East

Extension Health is led by Dr. Albert Kuo and has two Manhattan locations. It publishes its pricing at $10,000 per session, self-pay only, and has published its own data, including a 77% reduction in BPA (bisphenol A, a plastic-derived chemical) after TPE. Its educational content is extensive, and two locations mean more scheduling flexibility.

Next Health: Flatiron

Next Health is a national chain with 15-plus locations. The Flatiron location offers TPE within a membership model alongside aesthetics and IV services. It publishes bundle pricing of $24,000 for three sessions and $45,000 for six, and its program includes a Baseline Test and a Total Tox Burden Test. The chain model means standardized systems and a national brand rather than a single named physician relationship.

What Actually Matters When Choosing a TPE Clinic

The question I hear most is “which one should I go to?” The honest answer depends on what you prioritize, but five factors are genuinely clinical rather than a matter of preference.

Physician oversight. TPE is a medical procedure with real contraindications. The person responsible for your protocol should be a licensed physician who has reviewed your history, medications and labs. Ask which physician will be accountable for clinical decisions, and whether that person will actually see you.

Lab tracking. If a clinic does not measure your biomarkers before and after treatment, you cannot know whether it is working for you specifically. Ask what is measured before session one and what is measured afterward.

IVIG decision-making. In the 2025 Aging Cell trial, TPE combined with IVIG produced a 2.61-year average reduction in biological age markers, compared with 1.32 years for TPE alone. IVIG has its own contraindications and adds cost, so whether it belongs in your plan is a clinical determination, not a menu item. Our breakdown of the clinical trial evidence covers what the study did and did not show.

Protocol continuity. The trial used repeated sessions over a defined period. A clinic built around one-off sessions is a different proposition from one that manages a protocol over time.

Integration. Hormone therapy, NAD+ and peptides can all interact with recovery and lab interpretation. A clinic that treats TPE in isolation gives you less of the picture. For how Liondale approaches this, see concierge longevity medicine in NYC.

How Long Does a TPE Session Take?

Plan on two to three hours, seated and comfortable. One or two IV lines are placed, usually in the arms, and blood is drawn continuously into the apheresis machine, where plasma is separated and removed and your cells are returned with albumin solution. An anticoagulant, typically citrate, keeps blood from clotting in the circuit. Your blood pressure and heart rate are monitored throughout, and most patients read, work or rest. Exact time depends on body size, the volume exchanged and how well your veins tolerate the flow.

Does TPE Hurt, and What Does It Feel Like?

Most patients feel a brief pinch when the IV is placed and little discomfort afterward. Citrate can bind calcium, so some people notice tingling around the lips or fingers, cramping or mild nausea during the session. The team can usually resolve this by slowing the rate or giving calcium. Lightheadedness and fatigue afterward are common and typically pass within a day. Eat a meal and drink fluids beforehand, and plan a lighter schedule for the rest of the day. Our safety and candidacy guide covers side effects and who should not have TPE.

How Quickly Does TPE Work?

There is no fixed timeline, and it is worth being wary of anyone who promises one. Some patients report feeling different within days, but that is subjective. Plasma proteins change immediately because plasma is physically replaced, while markers such as inflammatory proteins and biological age estimates are judged across a series of treatments, not after one session. In the 2025 trial, biological age was assessed over a multi-month protocol. This is why we measure your response with labs rather than relying on how you feel the next morning.

What the Science Shows

The main evidence base is a randomized, placebo-controlled trial published in Aging Cell in May 2025 by the Buck Institute for Research on Aging and Circulate Health. It enrolled 42 healthy adults over 50. TPE with IVIG produced an average biological age reduction of 2.61 years, and TPE alone produced 1.32 years, measured with epigenetic clocks. Only two participants discontinued. This is one small trial that measured biomarkers, not lifespan or disease outcomes, so it is encouraging rather than conclusive. For the environmental-exposure question patients often raise, see can TPE remove microplastics from blood?

What Joe Rogan and Ben Greenfield Got Right

Joe Rogan described TPE as “changing the oil in your body,” and Ben Greenfield listed it among his top biohacks of the year. The oil-change analogy is a fair lay description: plasma is removed and replaced with fresh fluid. But neither mention tells you which clinic runs it well, whether a physician designs your protocol or whether your response is measured. Use them as a starting point for research, not a recommendation.

Combining TPE With Other Treatments

Many patients pair TPE with NAD+ IV therapy, medical ozone therapy or hormone care. These work through different mechanisms and generally do not conflict, though we space them to avoid overlapping recovery windows. If you are weighing options, TPE compared with NAD+, ozone, stem cells and peptides lays out the trade-offs. We also cover TPE versus donating blood for patients who ask.

TPE Near Me: Getting to Liondale Medical

Liondale Medical is at 10 West 74th Street, Suite 1E, New York, NY 10023, on the Upper West Side. You can reach us at 212-579-9136. Because your consultation and baseline labs come first, your initial visit does not need to be a treatment day. If you are comparing options nearby, why patients choose Liondale for TPE in NYC explains how our care model works.

Do I Need a Referral?

No referral is required. Contact us directly to schedule a consultation. Dr. Bissoon reviews your history, medications and recent labs, and if TPE is appropriate we design your protocol at that visit. If it is not, we tell you.

Questions to Bring to Your Consultation

A good consultation is a two-way conversation, so it helps to arrive prepared. Bring recent bloodwork, a full list of medications and supplements, and a short summary of what you hope TPE will change. Then ask the physician directly how your protocol would be designed, which labs will be drawn before and after each session, and how the plan changes if your markers do not move. Ask what would make you a poor candidate, and what the alternatives would be if TPE is not the right fit. Ask who is present during the session and who reviews your results afterward. Finally, ask what is included in the price, what is billed separately and what a realistic maintenance plan looks like after the initial series. Clear, specific answers tell you more about a clinic than any brochure or podcast mention. Write the answers down so you can compare clinics fairly. If a provider is vague about candidacy, lab tracking or physician involvement, treat that as useful information. You can see how we answer these questions in how Liondale tracks TPE results and why patients choose Liondale for TPE in NYC.

Frequently Asked Questions

Is TPE the same as plasmapheresis?

Yes. Plasmapheresis and therapeutic plasma exchange describe the same procedure: blood is drawn, plasma is separated and removed, and a replacement fluid such as albumin is infused while your blood cells are returned. You may also see it called plasma exchange therapy or apheresis.

Where can I get therapeutic plasma exchange in NYC?

Three clinics currently offer TPE for longevity in New York City: Liondale Medical on the Upper West Side, Extension Health in the West Village and Midtown East, and Next Health in Flatiron. They differ in physician oversight, lab tracking, pricing structure and how TPE is integrated with other care.

How much does TPE cost in NYC?

Published pricing at NYC clinics ranges from about $8,000 to $10,000 per session, with bundle pricing at one chain. Liondale discusses pricing at consultation because cost depends on your protocol. TPE for longevity is self-pay and is not covered by insurance. See our TPE cost guide for a full breakdown.

How long does a plasma exchange session take?

Plan for two to three hours. The exact time depends on your body size, the volume of plasma exchanged and how well your veins tolerate the flow rate.

Is plasma exchange painful?

Most patients feel a brief pinch when the IV is placed and little discomfort afterward. Some notice tingling around the mouth or fingers from citrate, which the team can usually address by adjusting the rate or giving calcium.

How quickly does plasma exchange work?

There is no universal timeline. Plasma proteins change immediately, but inflammatory markers and biological age markers are judged across a series of sessions and confirmed with labs. Some patients report feeling different within days, which is subjective.

What is the difference between TPE and young blood transfusions?

They are different procedures. TPE removes your own plasma and replaces it with albumin, not donor blood products. Young plasma infusions involve receiving plasma from younger donors, and their evidence base and risk profile are different and more limited.

Do I need a referral for therapeutic plasma exchange?

No referral is required at Liondale. You contact us directly to schedule a consultation, where Dr. Bissoon reviews your history, medications and recent labs.

What are the risks and side effects of therapeutic plasma exchange?

Common effects are temporary: fatigue, lightheadedness, tingling from calcium shifts and bruising at the IV site, usually resolving within 24 hours. Serious adverse reactions are uncommon. Screening before treatment reduces risk. Read the full safety and candidacy guide.

Can I combine TPE with NAD+ or ozone therapy?

Generally yes, as these work through different mechanisms. We typically space treatments to avoid overlapping recovery windows, and sequencing is planned at consultation with your labs in hand.

How do I know if I’m a good candidate?

The consultation and baseline labs answer that. Adults with elevated inflammatory markers, environmental exposure concerns or metabolic markers trending the wrong way are the profiles most likely to be considered. Patients with pristine baseline labs may see smaller effects, and we say so honestly.

Is a “blood oil change” the same as TPE?

The phrase is a lay description of TPE, in which plasma is removed and replaced. Some clinics apply similar language to other treatments that do not replace plasma, so ask exactly what procedure is being performed.

To find out whether you are a candidate for TPE, schedule a consultation with Dr. Bissoon. You can also read our full TPE service page for the clinical overview.