Blog Articles

Three clinics in New York City currently offer therapeutic plasma exchange for longevity and anti-aging: Liondale Medical on the Upper West Side, Extension Health in West Village and Midtown East, and Next Health in Flatiron. Published pricing ranges from $8,000 to $10,000 per session...

Most TPE clinics perform the procedure and send you home. At Liondale, every session is bracketed by a pre-treatment baseline draw and a post-treatment follow-up panel. We measure the same markers before and after: CRP, IL-6, fibrinogen, a metabolic panel, a lipid panel, and where clinically relevant, epigenetic clock biomarkers...

Yes, therapeutic plasma exchange has a strong medical safety record when it is performed in the right setting, with the right screening, and for the right patient. Large retrospective studies report serious adverse events in roughly 0.12% of procedures, and TPE has decades of clinical use behind it in both autoimmune...

Liondale Medical is one of only three NYC practices currently offering therapeutic plasma exchange for longevity. What separates it is not a louder claim. It is the care model: physician-led oversight by Lionel Bissoon, D.O., a Circulate Health partnership that informs how the practice approaches TPE, pre- and...

Concierge longevity medicine is physician-led, lab-driven care for patients who want a real medical strategy for aging well, not a menu of trendy treatments sold one by one. At Liondale Medical on the Upper West Side, Dr. Lionel Bissoon, D.O., builds that strategy around baseline testing, direct physician oversight...

There is no proven everyday intervention for removing microplastics from blood. The honest answer is that researchers are still working out what microplastic accumulation in human tissue means clinically, let alone how to address it. Therapeutic plasma exchange is being discussed in this context because it physically removes and replaces the plasma fraction of blood...

Does TPE work? Based on the best direct human evidence we have right now, yes, therapeutic plasma exchange appears to improve biological age biomarkers under controlled study conditions. In the May 2025 Aging Cell trial, TPE plus IVIG reduced biological age by an average of 2.61 years, while TPE alone reduced it by 1.32 years...

If you are comparing longevity treatments, therapeutic plasma exchange has the strongest published case for measurable biological age reduction among the options on this list. NAD+ IV therapy is broader, less aggressive, and far less expensive, which makes it a sensible entry point for many patients...

Aging isn’t just about a number. Sometimes your hormones run ahead of the timeline, quietly shifting your energy, mood, metabolism, and more. Here are some hidden signs that your hormones are aging quickly.

If the idea of getting older makes you anxious, you’re not alone. The good news? While you can’t stop time, you can take steps now to make your future self healthier, stronger, and more at ease. Here are five proactive moves for a healthier future.

Feeling “off” lately but can’t put your finger on why? Low energy, brain fog, poor sleep, or mood swings are often brushed off as stress or aging. But hormones may be part of the story. If so, BHRT (bioidentical hormone replacement therapy) can help.

You stayed up late scrolling. Now, you’re tired, lack focus, and feel overwhelmed by simple tasks. Enter NAD+ IV therapy, a revitalizing treatment that recharges cells and boosts your energy. Here’s why you should consider NAD+.

Your gut isn’t just about digesting last night’s dinner. It’s home to trillions of bacteria (your microbiome) that support entire body systems — and even help elevate your mood. If your gut's out of whack, you may feel a bit off. Here’s why.

Many of us don’t call our doctor until something feels “off.” That’s sick care — reactive, short-term fixes after symptoms show up. Instead, true health care focuses on smarter choices aimed at prevention.

Alzheimer’s disease is the most common form of dementia — AKA, memory loss that interferes with your quality of life. It affects millions, mostly older adults, and right now there’s no cure. But there’s good news: there are ways to reduce your risk. 

Curious about testosterone therapy but not sure if receiving shots is right for you? Testosterone replacement therapy can dramatically alter your life if you struggle with low T. Here’s why.

So you finally made it to the gym. You’re mid-squat or halfway through spin class, and bam — a headache. Not exactly the endorphin rush you signed up for. What gives? Your hormones and workouts are in a complicated relationship. Here’s why.

If your hair sheds at a scary pace, your hormones might be the culprit. Find out the top places where hormonal hair loss occurs — plus why it’s happening, and how to stop it.

Let’s talk about the extra fluids and nutrients your body didn’t know it needed. Intravenous (IV) therapy infuses fluids, vitamins, or medications straight into your bloodstream. Here are some reasons to choose IV therapy for better health.

Ozone therapy (yes, the stuff that makes up part of our atmosphere) has been making waves for its potential health benefits. The idea? It increases oxygen in the body, offering an array of health benefits. Here’s why you should consider it.

Testosterone plays a key role in energy, mood, muscle mass, and sexual function. But especially as we age, testosterone levels can change. Discover the 12 warning signs of testosterone imbalance that may warrant a doctor visit.

You don’t have to accept weight gain, muscle loss, and thinning hair as inevitable signs of aging. Bioidentical hormone replacement therapy may offer the solution you’re looking for, helping you age gracefully while maintaining a youthful appearance.

By the time you’re middle-aged, you have about half of the powerful co-enzyme NAD you had in your youth. NAD therapy restores your NAD levels, giving you impressive anti-aging benefits.

High T: Lionel Bissoon (above) has seen a rise in demand for testosterone from Wall Street workers.

One day, Meghan O’Rourke started experiencing “electrical shocks” throughout her legs and arms - a spasming and itchiness that left doctors confused. Like many other patients, the doctors all sent her home with simple hypotheses and a “wait-and-see” treatm

Regenerative Cellular Medicine could Treat Frailty in Old Age

Want to know how to stay young, fit and energized? Learn how all the major New York executives do it in Dr. Lionel Bissoon's interview with the New York Post, "How Wall Street and tech bros are staying forever young." Read the original article on the New

Women make up the majority of Alzheimer’s cases. While scientists don’t fully understand all of the mechanisms behind women’s increased risk factor, researchers have found one treatment to help curb the onset of Alzheimer’s: hormone replacement therapy.

Could your sleep habits cause wrinkles? What other lifestyle choices will keep us looking forever young? Dr. Lionel Bissoon was invited to weigh in on LIVESTRONG.COM's list of top Anti-Aging tips. Which of these skin sins are you committing?

Watch! Magazine got in touch with Dr. Bissoon to find out his top 5 anti-aging tips for men. Read the article below, or download the article in its full form.

In the Body & Soul section of Watch Magazine (December 2012), an Anti-Aging article highlights Dr. Lionel Bissoon's Anti-Aging Therapies. Read his advice below, or download a PDF of the article!

Executives and professionals in the United States have been seeking a controversial and expensive hormone replacement therapy to combat effects usually associated with stress and aging.

Every morning, Kay Brown engages in a ritual similar to a heroin addict’s, or a diabetic’s: she sticks herself with a syringe. Only hers contains hCG, a pregnancy hormone.