How Much Does Therapeutic Plasma Exchange (TPE) Cost in NYC?

A single session of therapeutic plasma exchange (plasmapheresis) runs between $6,000 and $15,000 nationally, depending on the clinic, the protocol and whether intravenous immunoglobulin (IVIG) is included. In New York City, published pricing at the three active TPE clinics ranges from about $8,000 to $10,000 per session. Patients who commit to an ongoing program typically spend $12,000 to $36,000 or more per year, and TPE for longevity or anti-aging is not covered by insurance. The rest of this page explains what that number buys, why prices differ, and how to compare providers fairly. For the clinical overview of our own program, see therapeutic plasma exchange at Liondale Medical.

TPE Cost at a Glance

Item	Typical range
Single session, national range	$6,000 to $15,000
Single session, published NYC pricing	About $8,000 to $10,000
Bundle pricing, NYC chain example	$24,000 for three sessions; $45,000 for six
Ongoing program, annual	$12,000 to $36,000 or more
Insurance coverage for longevity use	None
HSA/FSA	Possibly, depending on your plan

Ranges reflect published clinic pricing and can change. Liondale prices are set at consultation.

What You Are Actually Paying For in a TPE Session

TPE is not an IV drip. It is a medical procedure that takes two to three hours, uses an apheresis machine that costs hundreds of thousands of dollars, requires a trained apheresis nurse and runs under physician supervision. Blood is drawn continuously, plasma is separated and discarded, albumin solution replaces it and your cells are returned to you. Your vital signs are monitored throughout.

Several components drive the price:

• Replacement fluid. Albumin is a significant cost, and the amount used depends on your size and protocol.
• Equipment and disposables. Each procedure uses a single-use apheresis circuit and supplies.
• Staffing. Apheresis nursing and physician oversight, which varies from an on-site physician to a remote sign-off.
• Laboratory testing. Baseline and follow-up panels, and whether they are included or billed separately.
• IVIG. When it is part of a protocol, it adds cost and carries separate contraindications.
• Number of sessions. The initial series and the maintenance schedule.

The procedure is only part of the value. What happens around it matters at least as much: do you get baseline labs before session one, do you get post-treatment labs to see what changed, and does a physician review the results and adjust your plan?

What Is Included at Liondale

At Liondale, the pre- and post-treatment lab panel accompanies every session. We measure inflammatory markers (CRP, IL-6, fibrinogen), a metabolic panel and, where clinically relevant, epigenetic clock biomarkers. Dr. Bissoon personally reviews each patient’s results. The cost reflects that: you leave knowing what changed, not only how you felt. The reasoning behind this approach is laid out in how Liondale tracks TPE results.

Pricing is discussed at consultation rather than posted, because your protocol determines it. Whether IVIG belongs in your plan is a clinical decision made from your history, not a package add-on.

How Many Sessions Will You Need, and What Does That Cost Over a Year?

For most patients we recommend an initial series of three to six sessions. Frequency is set by your labs and how you respond, not by a fixed menu. Some patients come in monthly for the first series, and others space sessions six to eight weeks apart. After the initial series, most move to quarterly or monthly maintenance depending on their labs and goals.

That structure is why annual cost varies so widely. A patient doing a three-session series and then quarterly maintenance has a very different year from one doing six sessions and monthly maintenance. When you compare clinics, compare the program, not only the per-session number. Ask what a realistic first-year plan would cost for someone with your goals.

TPE Cost in NYC: What Other Clinics Charge

Three clinics in New York City currently offer TPE for longevity:

• Extension Health (West Village and Midtown East), led by Dr. Albert Kuo: $10,000 per session, self-pay only. It has published its own data, including a 77% reduction in BPA after TPE.
• Next Health (Flatiron): $24,000 for three sessions and $45,000 for six. A national chain with 15-plus locations whose program includes a Baseline Test and Total Tox Burden Test, delivered as a membership.
• Liondale Medical (Upper West Side): pricing discussed at consultation. A boutique concierge practice and Circulate Health partner with pre- and post-treatment lab tracking at every session.

For national context, MDLifespan lists prices starting at $5,995 per session, and Dr. Allen P. Green in California publishes a range of $6,000 to $15,000. The spread reflects what is included: IVIG, lab panels, physician versus nurse oversight and chain infrastructure versus an independent practice. The cheapest option is not the wrong choice for every patient, but the physician oversight and lab tracking questions are worth asking directly. For a side-by-side view, see our comparison of NYC TPE clinics.

Why TPE Costs More Than Other Longevity Treatments

Patients often compare TPE with NAD+ IV therapy or ozone therapy, which cost a fraction as much per session. The difference reflects the procedure. TPE requires an apheresis machine, albumin replacement, specialized nursing and longer chair time. In our comparison of TPE, NAD+, ozone, stem cells and peptides, typical ranges are roughly $200 to $600 for NAD+ and $100 to $300 for ozone per session, against $6,000 to $15,000 for TPE. They are different tools with different evidence, not interchangeable price points. If budget is your main constraint, NAD+ IV therapy or medical ozone therapy may be a sensible place to begin.

Does Insurance Cover Therapeutic Plasma Exchange?

TPE for longevity is self-pay. Insurance does not cover it for this purpose, and no billing code pathway changes that. If a clinic suggests otherwise, ask them to put it in writing.

Insurance can cover plasma exchange for established medical indications, such as myasthenia gravis, Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy (CIDP) and several other autoimmune and neurological conditions, when your physician orders it for that condition. That is a different clinical situation from elective longevity care.

Can You Use HSA or FSA Funds for TPE?

Possibly. Some HSA and FSA plans allow physician-ordered treatments, and others classify longevity care as elective and exclude it. Confirm with your plan administrator before your first session. We can provide documentation of the clinical nature of the treatment to support your submission if needed.

Is TPE Worth the Cost?

I want to answer this honestly rather than reassuringly. The most significant evidence comes from a randomized, placebo-controlled trial published in Aging Cell in May 2025 by the Buck Institute for Research on Aging and Circulate Health. It enrolled 42 healthy adults over 50. TPE combined with IVIG produced an average biological age reduction of 2.61 years, and TPE alone produced 1.32 years, measured with epigenetic clocks. Two participants discontinued.

That is real data, and it is early data. It is one trial with 42 participants that measured biomarkers, not lifespan. It does not prove you will live longer or feel younger. For a plain-language summary of what it did and did not show, read our analysis of the 2025 TPE clinical trial.

If you have already addressed sleep, nutrition, exercise and stress, and you want an intervention with a real mechanistic rationale and a published controlled trial, TPE deserves serious consideration. It is not a shortcut around the fundamentals, and it is not right for every patient. Circulate Health’s post-procedure surveys report 90% patient satisfaction, which is a self-reported measure of tolerability and experience rather than a clinical outcome.

Safety Profile: What to Know Before Your First Session

TPE has been used in clinical medicine for more than 50 years. In large retrospective studies, serious adverse reactions occur in roughly 0.12% of procedures. Common side effects are mild and temporary: fatigue, lightheadedness, tingling from calcium shifts and bruising at the IV site. Patients with active bleeding disorders, certain clotting factor deficiencies, severe hemodynamic instability or albumin allergy are not candidates, and anticoagulants and some immunosuppressants need individual review. Our safety and candidacy guide covers screening in detail.

How to Compare TPE Providers on Cost

Before you commit to any clinic, ask these questions:

1. What is the total cost of the first three to six sessions, including labs?

2. Is IVIG included, optional or excluded, and what does it cost?

3. Which physician reviews my protocol, and will I see them?

4. What is measured before and after each session?

5. What does maintenance cost after the initial series?

6. What happens if my markers do not move?

Clinics that answer these clearly are easier to compare and easier to trust.

A Simple Way to Budget for TPE

Because pricing varies by protocol, it helps to build your budget in layers. Start with the consultation and baseline labs, since those tell you whether TPE is appropriate at all. Next, estimate the initial series, remembering that the number of sessions depends on your labs and how you respond. Then add the maintenance phase, which is where annual cost is really decided. Finally, ask whether IVIG is likely to be part of your plan, because it changes both the clinical picture and the total. Ask each clinic to describe these layers in writing so you can compare like with like, including anything billed separately. Patients who take this approach usually find that the cheapest quote is not always the cheapest program, and the most expensive quote is not always the most complete one. The goal is clarity before commitment. Our NYC TPE clinic comparison can help you frame the questions, and our safety and candidacy guide explains why screening comes before any pricing conversation.

Frequently Asked Questions

How much does therapeutic plasma exchange cost in NYC?

Published pricing at NYC clinics runs about $8,000 to $10,000 per session, and nationally $6,000 to $15,000 depending on protocol and whether IVIG is included. Ongoing programs typically cost $12,000 to $36,000 or more per year. Liondale provides pricing at consultation because it depends on your protocol.

How many sessions will I need?

Most patients start with three to six sessions in the initial series. Frequency is determined by baseline labs and how your markers respond. After the initial series, most move to monthly or quarterly maintenance. There is no universal protocol, and we design yours from your data.

How long does each session take?

Plan for two to three hours, seated and comfortable. One or two IV lines are placed at the start, and you can read, work or rest. Temporary fatigue or mild lightheadedness afterward typically resolves within a day.

Is plasmapheresis the same as therapeutic plasma exchange, and does it cost the same?

Yes. Plasmapheresis and therapeutic plasma exchange are the same procedure. “Plasmapheresis” is more common in hospital and autoimmune settings, while “therapeutic plasma exchange” is the term longevity clinics tend to use. Pricing for longevity use is the same range, $6,000 to $15,000 per session depending on clinic and protocol.

Does insurance cover therapeutic plasma exchange?

Not for longevity or anti-aging purposes. Insurance may cover plasma exchange for established indications such as myasthenia gravis, Guillain-Barre syndrome and CIDP when a physician orders it for that condition.

Can I use HSA or FSA funds?

Possibly. Some plans allow physician-ordered treatments and others exclude longevity care as elective. Confirm with your plan administrator before your first session. We can provide documentation of the clinical nature of the treatment if needed.

What labs are included at Liondale?

Every patient receives a pre-treatment baseline panel and a post-treatment follow-up panel covering inflammatory markers (CRP, IL-6, fibrinogen), a metabolic panel, a lipid panel and, where appropriate, epigenetic clock biomarkers.

Why is TPE so much more expensive than NAD+ or ozone therapy?

TPE requires an apheresis machine, albumin replacement fluid, specialized apheresis nursing, physician oversight and two to three hours of chair time. NAD+ and ozone are simpler infusions with different mechanisms and evidence.

Can I combine TPE with NAD+ or other treatments?

Many patients do. Whether it makes sense depends on your medications, recovery tolerance and lab goals. In some cases we sequence treatments to avoid overlapping recovery windows.

Who should not have TPE?

Patients with active bleeding disorders, certain clotting factor deficiencies, severe hemodynamic instability or albumin allergy are not candidates. Patients on anticoagulants or some immunosuppressants need careful evaluation first. The consultation and baseline labs identify these issues.

How do I know if TPE is working?

The post-treatment lab panel tells you. We compare inflammatory markers, metabolic markers and, where relevant, biological age markers before and after treatment, and adjust the protocol if they are not moving as expected.

What are the side effects of TPE?

Common effects are temporary fatigue, mild lightheadedness, tingling from calcium shifts and bruising at the IV site, usually resolving within 24 hours. Serious adverse events are rare, and screening before your first session reduces risk.

To discuss your protocol and a realistic first-year plan, schedule a consultation with Dr. Bissoon. You can also read about TPE at Liondale Medical or see why patients choose Liondale for TPE in NYC.